The Best Medicine For Anxiety Disorders SSRIs and SNRIs like citalopram, Escitalopram, fluoxetine (Prozac) Venlafaxine, citalopram and duloxetine are treatments of first line for anxiety disorders. Psychotherapy and exercise are also important for people with anxiety. Antihistamines like hydroxyzine (Atarax, Vistaril) are prescribed by a few doctors. They aid in